Ppt coase theorem powerpoint presentation free to view. Supramolecular chemistry is an up to date, integrated textbook that tells the newcomer to the field everything. Interaction energies were calculated through the nbodel procedure. The number n enclosed in brackets, which separates calix and arene, indicates the number of aromatic ring units in the macrocycle, for example, calix4arene, calix6arene and. Applications of calixarenes in cancer chemotherapy. Roundhill, in comprehensive coordination chemistry ii, 2003. Calix4arene calix8arene calix6arene calix8 calix4 derivative calix8 14 carbons are present in c nmr of derivative calix4 derivative. People can view the slides even if they dont have powerpoint, but they cant make changes to it. The synthesis and characterization of giant calixarenes nature. Calixarenes are macrocyclic oligomers, formed from phenolformaldehyde condensation. There are some 3,000 publications reporting calixarenes, many of which can be obtained by searching databases under the term calix. Save powerpoint presentations as pdf files office support.
The aromatic components are derived from phenol, resorcinol, or pyrogallol to give, respectively, calixarenes, resorcinarenes, and pyrogallolarenes. Davis and viviane boyer dyson perrins laboratory, university of oxford, south parks road, oxford, uk ox1 3qy. Important calixarene derivatives their synthesis and. Calixarenes can be used as ion sensitive electrodes or sensors4, optical sensors5, chiral recognition devices for solid phase extraction, as a stationary phase and modifiers6. However, calixarene host molecules have a unique composition that include benzene groups, which. This book contains extensive references to recent literature, offering the reader a. In order to study these interactions, nmr, uvvis, fluorescence, mass spectroscopy and finally crystal structures will be used. Calixarenes of varying cavity size can form variety of hostguest type of inclusion complexes similar to cyclodextrins. Along with their intrinsic fundamental interest, these objects are also opening interesting applicative potentialities. Calixarene c56h72o12 cid 3081771 structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety. Supramolecular hostguest inclusion complexes were formed by hydrophobic interactions, hydrogen bonding. Controlled drug delivery systems based on calixarenes. For phenol, the aldehyde most often used is simple formaldehyde, while larger aldehydes, like acetaldehyde, are usually required in condensation reactions with resorcinol and pyrogallol to facilitate formation of the c4v symmetric vase. Supramolecular chemistry is chemistry beyond the molecule the chemistry of molecular assemblies and intermolecular bonds.
Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that. The shape of calixarenes is like a cup or a bucket with a defined upper and lower rim along with a central annulus. A calixarene is a macrocycle or cyclic oligomer based on a hydroxyalkylation product of a. Jul 20, 2018 the exposed calixarenes can be used for the visual detection and encapsulation of no 2 through the formation of deeply colored chargetransfer complexes inside the mof. Click create pdf xps document, then click create pdf xps. Calixarenes and their applications from the perspective of their creator, carl david. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. In the publish as pdf or xps dialog box, choose a location to save the file to. Calixarenes have hydrophobic cavities that can hold smaller molecules or ions and belong to the class of cavitands known in hostguest chemistry. Both the upper and lower rims can be tailor made to provide highly preorganized structures. Besides classical calixarenes, also calixarenes containing modified meso bridges are known,22 they are calixradialenes,23 ketocalixarenes24 and homocalixarenes.
Determination of calixarene conformations by means of nmr techniques. Pdf calixarenes are cyclic oligomers obtained by condensation of suitable pfunctionalised. Amphiphilic calixarenes and selfassembly as nanoparticles. Soft ionization is a useful technique when considering biological molecules of large molecular mass, such as the aformetioned, because this process does not fragment the. There is no covalent bonding between guest and host, the attraction being. Sensitivedetectionofheavymetalsionsbasedonthecalixarene. Besides, asv only involves regular a pparatus, such as a potentiometer, electrodes. Calixarenes as sensor materials for recognition and. University of wisconsin 19471951 under william summer johnson warf postdoctoral fellow at u. Determination of calixarene conformations by means of nmr. Syntheses, structures and interactions of heterocalixarenes pdf. Electrospray ionization is a soft ionization technique that is typically used to determine the molecular weights of proteins, peptides, and other biological macromolecules. Pdf functionalization reactions of calixarenes researchgate.
Files are available under licenses specified on their description page. Research on the therapeutic applications of calixarene derivatives is an emerging area of interest. Calixarene extractants for radiowaste partition is the property of its rightful owner. Important calixarene derivatives their synthesis and applications. Itally, jan 27feb 1, 20, poster and oral presentation. Calixarenebased receptors for molecular recognition. Calixarenes having larger cavity size like calix8arenes can also be ipso substituted31. All structured data from the file and property namespaces is available under the creative commons cc0 license. Calixarenes are cyclic oligomers obtained by condensation reactions between paratbutyl phenol and formaldehyde. Calixarenes are a well known class of macrocyclic compounds 1, obtained in very high yield through a onestep condensation of formaldehyde with ptert butyl phenol. David gutsche macromolecular people aman imani macalester college, mn 2.
Supramolecular theranostics nanosystems are delivered selectively to the tumors. Numerous research groups have reported cabased drug delivery systems by loading drugs in different inclusion. Scribd is the worlds largest social reading and publishing site. Calixarenebased nanoformulation for ocular delivery of. Calixarene, ionselective electrode, sensor, synthesis, enatioselective, optodes introduction the calixarenes are a class of cyclooligomers formed via a phenolformaldehyde condensation. Both regioisomers represent inherently chiral compounds, which makes them very attractive for design of novel receptors. Carboxylated calixarenes acting as glycomimeticsin immunoactivation karel krenek. V arious analytical applications of calixarenes are discussed. Calixarenes article about calixarenes by the free dictionary.
Applications of calixarenes as extractants and sensors 2. Fullerene an allotrope of carbon the most famous fullerene is c60 discovered by h w kroto and r smalley at rice university,usa 1985 popularly known as buckministerfullerene in honour of the american architect buckminister fuller the. Ppt calixarene powerpoint presentation, free download. Electrospray ionization mass spectrometry chemistry. Analytical applications of calixarenes from 2005 uptodate article pdf available in journal of inclusion phenomena 691.
Calixarenebased nanoformulation for ocular delivery of curcumin. By judicious choice of base, reaction temperature, and reaction time, calixarenes having different ring sizes can be prepared in good yield. The optical detector was based on a calix4arene to which a nitrophenylazophenol chromophore is attached. As in previous studies, all calixarenes were optimized along with their corresponding guests within the cavity, namely h 3 aso 4, h 2 aso 4 and haso 4 2at the dft level with the socalled minnesota functionals by truhlar and cao, m062x631gd,p level of theory.
The primary compromise in highresolution nmr is accepting large systematic, but reproducible errors if procedures are correctly followed in the measured. A calix4arene has 4 units in the ring and a calix6arene has 6. Cyclodextrins, calixarenes, cucurbiturils and crown ethers are readily synthesized in large quantities, and are. If so, share your ppt presentation slides online with. Macrocycles are very useful in supramolecular chemistry, as they provide whole cavities that can completely surround guest molecules and may be chemically modified to finetune their properties. Pdf the synthesis and characterization of giant calixarenes. These were transferred to microsoft powerpoint 97 in order to illustrate. Ppt calixarene powerpoint presentation, free download id. The highly selective complexation was analyzed by uvvis and ir spectroscopy, and the stability of the material was confirmed by powder x. In addition, several books have been written on calixarenes, and metal complexes are described in all of them. It is one of todays fastest growing disciplines, crossing a range of subjects from biological chemistry to materials science. Biocatalysis and enzymes in organic synthesis benjamin g. An introduction 2nd edition provides a concise overview of the field with particular attention to the historical development of calixarenes. They have the ability to bind to a variety of ions and find applications as ion sensors.
As demonstrated by pdcatalyzed arylation, the different reactivity of hgcl functions. It provides a fascinating and lively account of the history, development and applications of calixarenes, which are probably the worlds most readily available. An introduction monographs in supramolecular chemistry by c. Calixarenes are macrocycles that are made from phenol or ptertbutylphenol calixarenes and its derivatives can be used to complex a range of cations, anions and neutral molecules. The curriculum shall cover both artificial and biological systems as well as applications. Chapter 2 synthesis and characterization of calix4arene. Introduction there is considerable interest in developing e cient arti cial receptors for molecular recognition and sensing as. Supramolecular chemistry is an uptodate, integrated textbook that tells the. Biological applications of functionalized calixarenes. Calixarenes chelationcomplexation compounds sigmaaldrich. Perform the following steps with more details provided below. They are sparingly soluble and high melting solids. Fullerene an allotrope of carbon the most famous fullerene is c60 discovered by h w kroto and r smalley at rice university,usa 1985 popularly known as buckministerfullerene in honour of the american architect buckminister fuller the shape of c60 resembles the dome structure based on hexagons and pentagons.
A complex in which one component the host forms a cavity or, in the case of a crystal, a crystal lattice containing spaces in the shape of long tunnels or channels in which molecular entities of a second chemical species the guest are located. As demonstrated by pdcatalyzed arylation, the different reactivity of. Chemotherapy occupies a pivotal position in the treatment of cancer, and its significance in terms of cure and regression of various types of cancer should not be underestimated. When you save presentation as a pdf file it freezes the formatting and layout. This book contains extensive references to recent literature, offering the reader a valid. Swager department of chemistry, massachusetts institute of technology, cambridge, massachusetts 029, united states. Pdf analytical applications of calixarenes from 2005 up. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Calixarene, receptor, hostguest, drugs, chiral, lipase 1. Cucurbitnurils cbns, along with crown ethers, cyclodextrins, and calixarenes, are the fourthgeneration macrocyclic hosts that have played crucial roles in supramolecular chemistry in recent decades 1115.
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